Fluorine has become vital to the development of drugs, agrochemical agents and fine materials, but is almost exclusive to anthropogenic organic compounds. Now an emerging field, organofluorine chemistry requires greener chemical processes and shorter syntheses due to its increased number of applications. To achieve this goal, the Hamel group uses catalysis as a keystone for the development of fluorinative transformations, to functionalize fluorinated compounds and to enable defluorinative processes through chemo-, regio- and enantioselective C–H, C–C and C–F bond scission. Those aspects are reflected in the four components of our research program.